Multiple studies support the efficacy of nicotinamide and clindamycin in acne treatment: A double-blind study showed 4% nicotinamide gel produced comparable results to 1% clindamycin gel, with 82% improvement in the nicotinamide group versus 68% in the clindamycin group 3 Clindamycin + Nicotinamide is a combination of two medicines: Clindamycin and Nicotinamide, which treats pimples (acne). Clindamycin is an antibiotic which works by penetrating into the skin and killing acne-causing bacteria. In this article, we will explore the benefits of clindamycin and nicotinamide gel, how to apply it, its recommended dosage, potential side effects, and how it compares to other acne treatments. Dr. Alpana, MD, DNB, IFAAD explains what clindamycin and nicotinamide gel is and how it is to be used. Clindamycin is an antibiotic that works by inhibiting bacterial growth and decreasing skin inflammation. On the other hand, nicotinamide (vitamin B3) has anti-inflammatory and skin-soothing effects. It reduces skin redness, swelling, and irritation and supports healing. Clindamycin+nicotinamide is a topical gel primarily prescribed for the treatment of mild to moderate acne. It works by targeting the bacteria that cause acne breakouts and reducing the redness and swelling associated with inflamed pimples. Clindamycin+Nicotinamide is a combination medicine. It is used to treat acne and pimples. It also helps in reducing acne scars, whiteheads and blackheads. Clindamycin belongs to an antibiotic group of medicine and nicotinamide (niacin) is a form of vitamin B3. Clindamycin + Nicotinamide is a combination of two medicines: Clindamycin and Nicotinamide, which treats pimples (acne). Clindamycin is an antibiotic which works by penetrating into the skin and killing acne-causing bacteria. Clindamycin is an antibiotic that works by stopping bacteria from producing the proteins they need to grow and multiply. This reduces the population of acne-causing bacteria on the skin. Nicotinamide, also known as niacinamide, has anti-inflammatory properties that help calm redness and swelling. Clindamycin is an antibiotic that fights bacteria in the body. Clindamycin is used to treat serious infections caused by bacteria. Clindamycin is usually available as one of three salts: clindamycin phosphate, clindamycin hydrochloride, or clindamycin nicotinamide.